GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs4808801 | 1 | rs10164319 | chr19:18569833 | LRRC25 | chr19:18501955-18508421:- | -0.15 | -7.18 | 1.27E-12 | Breast cancer |
| BRCA | cis | rs4808801 | 1 | rs10164323 | chr19:18569492 | LRRC25 | chr19:18501955-18508421:- | -0.14 | -6.91 | 8.06E-12 | Breast cancer |
| BRCA | cis | rs6547741 | 1 | rs10165098 | chr2:27796526 | KRTCAP3 | chr2:27665263-27667163:+ | -0.13 | -4.03 | 6.02E-5 | Oral cavity cancer |
| BRCA | cis | rs11125529 | 1 | rs10165485 | chr2:54481636 | C2orf73 | chr2:54558071-54588714:+ | 0.18 | 4.59 | 5.05E-6 | Telomere length |
| BRCA | cis | rs2888875 | 1 | rs10165527 | chr2:43782868 | LOC100129726 | chr2:43454350-43455994:+ | 0.12 | 3.55 | 0.0004 | Glomerular filtration rate (creatinine) |
| BRCA | cis | rs6738490 | 1 | rs10165561 | chr2:234172915 | SAG | chr2:234216309-234255701:+ | 0.13 | 4.04 | 5.75E-5 | Crohn's disease |
| BRCA | cis | rs4665058 | 1 | rs10166544 | chr2:160140799 | WDSUB1 | chr2:160092305-160143236:- | 0.31 | 3.7 | 0.000226 | Sudden cardiac arrest |
| BRCA | cis | rs10170846 | 1 | rs10170846 | chr2:223517705 | FARSB | chr2:223436162-223520827:- | -0.16 | -4.67 | 3.4E-6 | Schizophrenia (inflammation and infection response interaction) |
| BRCA | cis | rs1364989 | 1 | rs1017280 | chr4:55011123 | FIP1L1 | chr4:54243820-54326102:+ | -0.19 | -4.25 | 2.29E-5 | Lupus nephritis in systemic lupus erythematosus |
| BRCA | cis | rs6487679 | 1 | rs1017302 | chr12:9367402 | LOC642846 | chr12:9436253-9466684:+ | 0.14 | 4.78 | 2.0E-6 | Non-alcoholic fatty liver disease histology (AST) |
| BRCA | cis | rs4038131 | 1 | rs10173181 | chr2:17780733 | GEN1 | chr2:17935162-17966632:+ | 0.14 | 3.39 | 0.000735 | Psychosis and Alzheimer's disease |
| BRCA | cis | rs1079204 | 1 | rs1017697 | chr2:219170462 | GPBAR1 | chr2:219125738-219128582:+ | -0.27 | -4.97 | 7.88E-7 | Smooth-surface caries |
| BRCA | cis | rs2382817 | 1 | rs1017698 | chr2:219170525 | TMBIM1 | chr2:219138917-219157280:- | -0.15 | -4.56 | 5.73E-6 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| BRCA | cis | rs2041840 | 1 | rs10177970 | chr2:37512968 | CEBPZ | chr2:37428778-37458740:- | 0.17 | 5.43 | 6.87E-8 | Chronic lymphocytic leukemia |
| BRCA | cis | rs2041840 | 1 | rs10178975 | chr2:37514564 | CEBPZ | chr2:37428778-37458740:- | -0.17 | -5.31 | 1.33E-7 | Chronic lymphocytic leukemia |